Cesium carbonate → HCID 90417507, compound

Participants

Reaction Steps

A mixture of Example 95A (3.26 g, 11.47 mmol), 2,4-difluorophenol (1.492 g, 11.47 mmol) and cesium carbonate (4.11 g, 12.61 mmol) in dimethyl sulfoxide (40 mL) was heated at 100° C. for 3 hours. The reaction mixture was partitioned with ethyl acetate and water. The organic layer was washed with saturated aqueous sodium chloride twice, dried with anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by flash chromatography (silica gel, 20 to 40% ethyl acetate in heptanes) to provide the title compound (3.98 g, 88%).

Provenance & Evidence