Cesium carbonate → HCID 86704958, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 3-bromo-4-fluorobenzaldehyde (500 mg, 2.46 mmol), 2,4-difluorophenol (0.353 mL, 3.69 mmol) and cesium carbonate (1204 mg, 3.69 mmol) in dimethylsulfoxide (24 mL) was heated at 105° C. overnight. The reaction mixture was partitioned between ethyl acetate (200 mL) and 50% saturated aqueous sodium chloride (200 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (2×75 mL). The combined organics were dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by flash column chromatography (silica gel, 2.5-100% ethyl acetate in heptanes) to afford the title compound (524 mg, 68% yield).

Provenance & Evidence