反应详情

3-Bromo-2-chloro-5-methylpyridine (4 g, 19.37 mmol), N-bromosuccinimide (3.79 g, 21.3 mmol) and benzoic peroxyanhydride (0.239 g, 0.969 mmol) were combined in carbon tetrachloride (40 mL), heated under reflux for 24 hours, cooled, and filtered to remove succinimide. The filtrate was concentrated. The resulting residue was purified by chromatography (silica gel, 0-30% ethyl acetate in heptanes) to afford the title compound (1.9 g, 34%).

1. temperatureheated
2. temperatureunder reflux for 24 hours
3. temperaturecooled
4. filtrationfiltered
5. customto remove succinimide
6. concentrationThe filtrate was concentrated
7. customThe resulting residue was purified by chromatography (silica gel, 0-30% ethyl acetate in heptanes)