反应详情

A mixture of Example 183A (200 mg, 0.338 mmol), tetrafluoroethanol (20 mL), and 5% Pd/C (45 mg, 0.188 mmol) in a 50 mL pressure bottle was stirred at ambient temperature for 16 hours under 30 psi of hydrogen and at ambient temperature. The mixture was filtered through a nylon membrane. The filtrate was concentrated to give the title compound (205 mg, 0.363 mmol, 101% yield), which was used without further purification.

1. filtrationThe mixture was filtered through a nylon membrane
2. concentrationThe filtrate was concentrated