Dimethylformamide → HCID 90417079, compound

Participants

Reaction Steps

A solution of Example 187A (3.24 g, 13.44 mmol) and dimethylformamide (37 mL) was cooled to 0° C. After the addition of 1-iodopyrrolidine-2,5-dione (3.6 g, 16.00 mmol), the reaction mixture was stirred at ambient temperature for 3 hours. The solution was cooled to 0° C. and 60 mL water was added followed by aqueous sodium bisulfate (60 mL, 10%) solution. The mixture was stirred for 1 hour at ambient temperature. Solid was collected by filtration, rinsed with water and was dried under vacuum to provide 4.9 g (99%) of the title compound.

Provenance & Evidence