참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | 4-Bromobenzyl bromide | HCID 68527 | — |
| 반응물 | Sodium methanesulfinate | HCID 2733271 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-Bromo-4-((methylsulfonyl)methyl)benzene | HCID 2761415 | 95.3% |
반응 단계
A 250 mL round-bottomed flask was charged with 4-bromobenzyl bromide (5 g, 20 mmol) and N,N-dimethylformamide (10.81 mL). Sodium methanesulfinate (3.06 g, 30 mmol) was added. The reaction mixture was stirred at 65° C. for 1 hour. The reaction mixture was cooled to ambient temperature and diluted with water. The resulting suspension was stirred for 10 minutes and filtered. The solid was rinsed with water and dried under vacuum to provide the title compound (4.75 g, 95% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09321764B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_04 |
|---|
| ORD ID | ord-c856bfc92c254b74a6a6d201d98b6e06 |
|---|
| 출처 메모 | uspto-grants-2016_04 |
|---|
