Potassium Carbonate → HCID 71186588, compound

Participants

Reaction Conditions

Reaction Steps

68 mg of potassium carbonate were added to a solution of 107 mg of tert-butyl [4-(5-methanesulfonyl-7-propyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]acetate in 1.1 ml of NMP, and 32 mg of 2,5-difluorophenol were then added. The reaction mixture was heated in a microwave synthesizer to 110° C. for 5 min and then cooled and poured onto ice. The precipitated compound was taken up in ethyl acetate, washed with water until neutral, dried over sodium sulfate, filtered and concentrated. The crude product was chromatographed on silica gel (heptane/ethyl acetate), giving 45 mg (38%) of the title compound.

Provenance & Evidence