3,3,3-Trifluoro-1-propanol → HCID 71187267, compound

HRID 633624Notes

Reaction equation

HRID 633624 reaction equation
[CH2:1]([C:5]1[C:6]2[N:17]=[C:16]([C:18]3[CH:32]=[C:31]([CH3:33])[C:21]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])=[C:20]([CH3:34])[CH:19]=3)[O:15][C:7]=2[N:8]=[C:9](S(C)(=O)=O)[N:10]=1)[CH:2]([CH3:4])[CH3:3].[F:35][C:36]([F:41])([F:40])[CH2:37][CH2:38][OH:39]>>[CH2:1]([C:5]1[C:6]2[N:17]=[C:16]([C:18]3[CH:32]=[C:31]([CH3:33])[C:21]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])=[C:20]([CH3:34])[CH:19]=3)[O:15][C:7]=2[N:8]=[C:9]([O:39][CH2:38][CH2:37][C:36]([F:41])([F:40])[F:35])[N:10]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 1375123,3,3-Trifluoro-1-propanolHCID 71187216HCID 71187216, compound

Product 1

HCID 71187267HCID 71187267, compoundYield 10%

Procedure

Analogously to example 2 (a), the reaction of 95 mg of tert-butyl [4-(7-isobutyl-5-methanesulfonyloxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]acetate with 3,3,3-trifluoropropan-1-ol gave 10 mg (10%) of the title compound.

Sources & evidence

ORD record
ord-406797cff9ee4b459f891401bee951ce
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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