Boron tribromide → HCID 136413236, compound

HRID 633633Notes

Reaction equation

[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([O:23]C)=[C:18]([CH3:25])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.B(Br)(Br)Br>>[Cl:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([OH:23])=[C:18]([CH3:25])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 71186280HCID 71186280, compound

Product 1

HCID 136413236HCID 136413236, compoundYield 84%

Procedure

Analogously to example 1 (e), the reaction of 850 mg of 5-(4-chlorobenzyl)-7-isobutyl-2-(4-methoxy-3,5-dimethylphenyl)oxazolo[5,4-d]pyrimidine with boron tribromide gave 690 mg (84%) of the title compound.

Sources & evidence

ORD record: ord-c9d0c3a405e940a3b3adb7f5c2144a92
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09321787B2

Reaction notes

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