tert-Butyl bromoacetate → HCID 71186466, compound

HRID 633634Notes

Reaction equation

HRID 633634 reaction equation
[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([OH:23])=[C:18]([CH3:24])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.Br[CH2:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34]>>[Cl:1][C:2]1[CH:30]=[CH:29][C:5]([CH2:6][C:7]2[N:8]=[C:9]([CH2:25][CH:26]([CH3:28])[CH3:27])[C:10]3[N:15]=[C:14]([C:16]4[CH:21]=[C:20]([CH3:22])[C:19]([O:23][CH2:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])=[C:18]([CH3:24])[CH:17]=4)[O:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 79177tert-Butyl bromoacetateHCID 136413236HCID 136413236, compound

Product 1

HCID 71186466HCID 71186466, compoundYield 92%

Procedure

Analogously to example 1 (f), the reaction of 684 mg of 4-[5-(4-chlorobenzyl)-7-isobutyloxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenol with tert-butyl bromoacetate gave 800 mg (92%) of the title compound.

Sources & evidence

ORD record
ord-4afeaeadc40e43cfbf262c8c5e758ede
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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