HCID 86675959, compound → HCID 71186593, compound

HRID 633637Notes

Reaction equation

HRID 633637 reaction equation
Cl[C:2]1[C:3]2[N:18]=[C:17]([C:19]3[CH:24]=[C:23]([CH3:25])[C:22]([O:26][CH3:27])=[C:21]([CH3:28])[CH:20]=3)[O:16][C:4]=2[N:5]=[C:6]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)[N:7]=1.[CH:29]([Mg]Br)([CH3:31])[CH3:30]>>[Cl:15][C:12]1[CH:11]=[CH:10][C:9]([CH2:8][C:6]2[N:7]=[C:2]([CH:29]([CH3:31])[CH3:30])[C:3]3[N:18]=[C:17]([C:19]4[CH:24]=[C:23]([CH3:25])[C:22]([O:26][CH3:27])=[C:21]([CH3:28])[CH:20]=4)[O:16][C:4]=3[N:5]=2)=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 86675959HCID 86675959, compoundHCID 178418365HCID 178418365, compound

Product 1

HCID 71186593HCID 71186593, compoundYield 11%

Procedure

Analogously to example 7 (d), the reaction of 1.5 g of 7-chloro-5-(4-chlorobenzyl)-2-(4-methoxy-3,5-dimethylphenyl)oxazolo[5,4-d]pyrimidine with isopropylmagnesium bromide gave 165 mg (11%) of the title compound.

Sources & evidence

ORD record
ord-05be8ab0067f41fdaf23b8788e09a89f
Source dataset
uspto-grants-2016_04
Patent number
US09321787B2

Reaction notes

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