HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(chloromethyl)-1-methyl-1H-indazole → HCID 118194302, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(chloromethyl)-1-methyl-1H-indazole | HCID 7537470 | — |
| Reactant | (S)-8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one | HCID 136238740 | — |
| Product | HCID 118194302 | HCID 118194302 | — |
Reaction Steps
180 mg (0.71 mmol) of (8S)-2-chloro-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one and 145.39 mg (0.78 mmol) of 3-chloromethyl-1-methyl-1H-indazole were used in the reaction. After purification by chromatography on silica gel (eluent: 80/20 DCM/MeOH), 250 mg of (8S)-2-chloro-9-(1-methyl-1H-indazol-3-ylmethyl)-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one are obtained, the characteristics of which are as follows:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321790B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-bcb80a0198ad4f9abf93f7c817e471dc |
| Source note | uspto-grants-2016_04 |