HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 63373Generated: October 25, 2026
Water → 4-(3-Furanyl)-2,6-dimethylphenol
https://huagongshe.com/reaction/63373
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Bromo-2,6-dimethylphenol | HCID 16919 | — |
| Reactant | Furan-3-boronic acid | HCID 2734358 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-(3-Furanyl)-2,6-dimethylphenol | HCID 90002523 | 68.7% |
Reaction Steps
4-Bromo-2,6-dimethylphenol (350 mg, 1.74 mmol), 3-furanylboronic acid (269 mg, 2.26 mmol), Pd(dppf)Cl2 (71 mg, 0.087 mmol) and sodium carbonate (553 mg, 5.22 mmol) were dissolved in DME:water=4 mL:2 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The obtained filtrate was extracted with ethyl acetate, dried over magnesium sulfate, and purified by column chromatography (hexane:ethyl acetate=9:1) to obtain 4-(furan-3-yl)-2,6-dimethylphenol (225 mg, 50%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09447083B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-2de7987e35f7458f8887fa5fbfa415af |
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| Source note | uspto-grants-2016_09 |
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