反应详情

A solution of 190 mg (1.19 mmol) of quinolin-5-ylmethanol in 5 ml of thionyl chloride is stirred for 10 minutes at room temperature and then refluxed for 2 hours. The reaction mixture is evaporated, the solid obtained is taken up in ethyl ether and the solution is filtered, washed with ethyl ether and dried to give 255 mg of 5-chloromethylquinoline hydrochloride, corresponding to the following characteristics:

1. temperaturerefluxed for 2 hours
2. customThe reaction mixture is evaporated
3. customthe solid obtained
4. filtrationthe solution is filtered
5. washwashed with ethyl ether
6. customdried