HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetramethylpyrazine → 2-(Bromomethyl)-3,5,6-trimethylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetramethylpyrazine | HCID 14296 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Product | 2-(Bromomethyl)-3,5,6-trimethylpyrazine | HCID 13584992 | — |
Reaction Steps
Dehydrated tetramethylpyrazine is dissolved into an organic solvent and then NBS is added at a mole ratio of tetramethylpyrazine to NBS=1:(0.5-0.7). The reaction liquid is then refluxed to react for 10-12 h. 2-bromomethyl-3,5,6-trimethyl pyrazine is obtained as a pale-red half-oily substance after post-treatment purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321804B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-7b9ad5099fe44d34abccace552641f4e |
| Source note | uspto-grants-2016_04 |