Benzoyl Peroxide → 2-(Bromomethyl)-3,5,6-trimethylpyrazine

Participants

Reaction Steps

Preferably, dehydrated tetramethylpyrazine is dissolved into CCl4 and then NBS is added at a mole ratio of tetramethylpyrazine to NBS=1:0.5. Adding a small amount of benzoylperoxide as the radical initiator is preferred. The reaction liquid is then refluxed to react for 10-12 h. 2-bromomethyl-3,5,6-trimethyl pyrazine is obtained as a pale-red half-oily substance after post-treatment purification.

Provenance & Evidence