反应详情

Dehydrated tetramethylpyrazine 10 g was dissolved into CCl4 60 ml and then NBS 9.17 g was added at a mole ratio of tetramethylpyrazine to NBS=1:0.7 (a minute amount of benzoylperoxide can be added as radical initiator). Reaction was carried out under reflux under the illumination of an incandescent lamp for 10-12 h. The reaction sample was cooled and condensed, and the excess tetramethylpyrazine was sucked away at a reduced pressure in 60-70° C. water bath. The residue was kept in a fridge for standing and a pale red half-oily substance 7.75 g was obtained with a yield of 70%.

1. additioncan be added as radical initiator)
2. customReaction
3. temperatureunder reflux under the illumination of an incandescent lamp for 10-12 h
4. temperatureThe reaction sample was cooled
5. customcondensed
6. customwas sucked away at a reduced pressure in 60-70° C.
7. customa pale red half-oily substance 7.75 g was obtained with a yield of 70%