HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 63382Generated: October 30, 2026
Water → 2-(Furan-2-yl)-4-methoxyphenol
https://huagongshe.com/reaction/63382
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Bromo-4-methoxyphenol | HCID 297382 | — |
| Reactant | Furan-2-boronic acid | HCID 2734357 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 2-(Furan-2-yl)-4-methoxyphenol | HCID 90002446 | 57% |
Reaction Steps
2-Bromo-4-methoxyphenol (400 mg, 1.97 mmol), 2-furanylboronic acid (287 mg, 2.56 mmol), Pd(dppf)Cl2 (81 mg, 0.1 mmol) and sodium carbonate (626 mg, 5.91 mmol) were dissolved in DME:water=4 mL:2 mL, followed by stirring in microwave at 120° C. for 20 minutes. After the completion of the reaction, the reaction mixture was filtered using Celite. The filtrate was added with water, and extracted with ethyl acetate. The obtained organic layer was dried over magnesium sulfate, and purified by column chromatography (hexane:ethyl acetate=9:1) to obtain 2-(furan-2-yl)-4-methoxyphenol (212 mg, 57%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09447083B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-e11e3cccab8549bbbce0fc5348802ad4 |
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| Source note | uspto-grants-2016_09 |
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