3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acid → HCID 178487789, compound

HRID 633822Notes

Reaction equation

HRID 633822 reaction equation
C(O[C:6](=[O:31])[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH:15]2[CH2:28][C:27]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:29][CH3:30])[CH:25]=4)[N:20]=[CH:19][C:18]=3[O:17][CH2:16]2)[CH2:10][CH2:9]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C(O)=O)[CH:41]=[CH:42][C:36]=2[O:35][CH2:34]1>>[CH3:30][O:29][C:24]1[CH:23]=[C:22]2[C:21](=[CH:26][CH:25]=1)[N:20]=[CH:19][C:18]1[O:17][CH2:16][CH:15]([CH2:14][C@H:11]3[CH2:10][CH2:9][C@H:8]([NH:7][C:6]([C:40]4[CH:41]=[CH:42][C:36]5[O:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)=[O:31])[CH2:13][CH2:12]3)[CH2:28][C:27]2=1

Participants

3

Reactant 2

HCID 7061213-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acidHCID 178487790HCID 178487790, compound

Product 1

HCID 178487789HCID 178487789, compound

Procedure

The titled compound is prepared as a white lyophilized powder following Scheme 4 and in analogy to Example 1 using [trans-4-(6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-cyclohexyl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid as starting material.

Sources & evidence

ORD record
ord-d43c732ded8846c59b1378ad124f20e8
Source dataset
uspto-grants-2016_04
Patent number
US09321788B2

Reaction notes

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