HRID633822

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID706121

3-Oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylic acid

C9H7NO4

结构：COc1ccc2ncc3c(c2c1)CC(C[C@H]1CC[C@H](NC(=O)OC(C)(C)C)CC1)CO3

HCID178487790

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2ncc3c(c2c1)CC(C[C@H]1CC[C@H](NC(=O)c2ccc4c(c2)NC(=O)CO4)CC1)CO3

HCID178487789

未命名化合物

PROCEDURE

实验过程

The titled compound is prepared as a white lyophilized powder following Scheme 4 and in analogy to Example 1 using [trans-4-(6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-cyclohexyl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carboxylic acid as starting material.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d43c732ded8846c59b1378ad124f20e8
来源数据集: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09321788B2
来源说明: uspto-grants-2016_04

反应 SMILES

C(O[C:6](=[O:31])[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][CH:15]2[CH2:28][C:27]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:29][CH3:30])[CH:25]=4)[N:20]=[CH:19][C:18]=3[O:17][CH2:16]2)[CH2:10][CH2:9]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C(O)=O)[CH:41]=[CH:42][C:36]=2[O:35][CH2:34]1>>[CH3:30][O:29][C:24]1[CH:23]=[C:22]2[C:21](=[CH:26][CH:25]=1)[N:20]=[CH:19][C:18]1[O:17][CH2:16][CH:15]([CH2:14][C@H:11]3[CH2:10][CH2:9][C@H:8]([NH:7][C:6]([C:40]4[CH:41]=[CH:42][C:36]5[O:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)=[O:31])[CH2:13][CH2:12]3)[CH2:28][C:27]2=1