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3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-piperidin-4-yl]-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid | HCID 760993 | — |
| 反応物 | 4-Amino-1-Boc-piperidine | HCID 1268291 | — |
| 反応物 | 3-bromomethyl-5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthrene | HCID 86730710 | — |
| 生成物 | 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid [1-(5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthren-3-ylmethyl)-piperidin-4-yl]-amide | HCID 71475525 | — |
反応手順
The titled compound is prepared as a white lyophilized powder following Scheme 1 and in analogy to Example 1 using 3-bromomethyl-5-fluoro-6-methoxy-3,4-dihydro-2H-1-oxa-9-aza-phenanthrene, 4-amino-piperidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321788B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-cbfae806eea648a491e560457c6dc52f |
| 出典メモ | uspto-grants-2016_04 |