3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 71475528, compound

HRID 633837Notes

Reaction equation

HRID 633837 reaction equation
Br[CH2:2][CH:3]1[CH2:17][C:6]2=[C:7]3[C:12](=[N:13][CH:14]=[C:5]2[O:4]1)[CH:11]=[CH:10][C:9]([O:15][CH3:16])=[N:8]3.C(OC([N:25]1[CH2:30][CH2:29][CH:28]([NH2:31])[CH2:27][CH2:26]1)=O)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40]([C:43](O)=[O:44])[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[CH3:16][O:15][C:9]1[CH:10]=[CH:11][C:12]2[C:7]([N:8]=1)=[C:6]1[CH2:17][CH:3]([CH2:2][N:25]3[CH2:26][CH2:27][CH:28]([NH:31][C:43]([C:40]4[CH:41]=[CH:42][C:36]5[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=5[CH:39]=4)=[O:44])[CH2:29][CH2:30]3)[O:4][C:5]1=[CH:14][N:13]=2

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 12682914-Amino-1-Boc-piperidineHCID 86730712HCID 86730712, compound

Product 1

HCID 71475528HCID 71475528, compound

Procedure

The titled compound is prepared as a white lyophilized powder following Scheme 1 and in analogy to Example 1 using 2-bromomethyl-8-methoxy-1,2-dihydro-3-oxa-5,9-diaza-cyclopenta[a]naphthalene, 4-amino-piperidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

Sources & evidence

ORD record
ord-b6dd6316e1854f19ac5f0bfee2ecfaa8
Source dataset
uspto-grants-2016_04
Patent number
US09321788B2

Reaction notes

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