3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 71475560, compound

HRID 633838Notes

Reaction equation

HRID 633838 reaction equation
Br[CH2:2][CH:3]1[O:17][C:6]2[CH:7]=[N:8][C:9]3[CH:10]=[CH:11][C:12]([O:15][CH3:16])=[CH:13][C:14]=3[C:5]=2[CH2:4]1.C(OC([N:25]1[CH2:30][CH2:29][CH:28]([NH2:31])[CH2:27][CH2:26]1)=O)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40]([C:43](O)=[O:44])[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[CH3:16][O:15][C:12]1[CH:11]=[CH:10][C:9]2[N:8]=[CH:7][C:6]3[O:17][CH:3]([CH2:2][N:25]4[CH2:26][CH2:27][CH:28]([NH:31][C:43]([C:40]5[CH:41]=[CH:42][C:36]6[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=6[CH:39]=5)=[O:44])[CH2:29][CH2:30]4)[CH2:4][C:5]=3[C:14]=2[CH:13]=1

Participants

4

Reactant 3

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 12682914-Amino-1-Boc-piperidineHCID 86730713HCID 86730713, compound

Product 1

HCID 71475560HCID 71475560, compound

Procedure

The titled compound is prepared as a white lyophilized powder following Scheme 1 and in analogy to Example 1 using 2-bromomethyl-8-methoxy-1,2-dihydro-furo[2,3-c]quinoline, 4-amino-piperidine-1-carboxylic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

Sources & evidence

ORD record
ord-e86d91400d574a468fb6e56b03935a5b
Source dataset
uspto-grants-2016_04
Patent number
US09321788B2

Reaction notes

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