Sodium periodate → HCID 86027543, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sodium periodate (2.88 g, 13.5 mmol, 1.2 eq) in water (30 mL) is added dropwise at 0° C. to a stirred solution of 3-(3-chloro-6-methoxy-quinolin-4-yl)-propane-1,2-diol (3.0 g, 11.2 mmol, 1.0 eq) in acetone (50 mL) and water (20 mL). After 30 minutes stirring at 0° C. the reaction mixture is extracted with ethyl acetate (3×100 mL) and water (100 mL). The combined organic layers are washed with brine, dried over sodium sulfate, filtered and concentrated to afford (3-chloro-6-methoxy-quinolin-4-yl)-acetaldehyde as a light brown solid (2.6 g, 99% yield).

Provenance & Evidence