Acetone → HCID 71118729, compound

Participants

Reaction Conditions

Reaction Steps

Sodium borohydride (2.09 g, 55.2 mmol, 1.0 eq) is added portionwise at 0° C. to a stirred suspension of (3-chloro-6-methoxy-quinolin-4-yl)-acetaldehyde (13.0 g, 55.2 mmol, 1.0 eq) in ethanol (200 mL). After 1 hour stirring at 0° C., acetone (50 mL) is added to quench the reaction. Solvents are removed and the resulting crude product is purified by column chromatography (silica gel, eluent: dichloromethane:methanol, 50:1, v/v) to afford 2-(3-chloro-6-methoxy-quinolin-4-yl)-ethanol as a yellow solid (13.1 g, 99% yield).

Provenance & Evidence