3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 178487795, compound

HRID 633844Notes

Reaction equation

HRID 633844 reaction equation
C(O[C:6](=[O:31])[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH:14]([OH:30])[CH:15]2[O:29][C:18]3[CH:19]=[N:20][C:21]4[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][C:26]=4[C:17]=3[CH2:16]2)[CH2:10][CH2:9]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C(O)=O)[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[OH:30][CH:14]([CH:15]1[O:29][C:18]2[CH:19]=[N:20][C:21]3[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][C:26]=3[C:17]=2[CH2:16]1)[C@H:11]1[CH2:12][CH2:13][C@H:8]([NH:7][C:6]([C:40]2[CH:41]=[CH:42][C:36]3[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=3[CH:39]=2)=[O:31])[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 178487796HCID 178487796, compound

Product 1

HCID 178487795HCID 178487795, compound

Procedure

The titled compound is prepared as a white lyophilized powder following Scheme 5 and in analogy to Example 1 using {trans-4-[hydroxy-(8-methoxy-1,2-dihydro-furo[2,3-c]quinolin-2-yl)-methyl]-cyclohexyl}-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

Sources & evidence

ORD record
ord-9ce1ba919ca745209e70d263e6ca22f3
Source dataset
uspto-grants-2016_04
Patent number
US09321788B2

Reaction notes

Loading…