3-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acid → HCID 71475543, compound

HRID 633854Notes

Reaction equation

HRID 633854 reaction equation
C([O:5][C:6](=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][C@@H:11]([CH2:14][CH:15]2[O:30][C:18]3[CH:19]=[N:20][C:21]4[CH:22]=[CH:23][C:24]([O:28][CH3:29])=[C:25]([F:27])[C:26]=4[C:17]=3[CH2:16]2)[O:10][CH2:9]1)(C)(C)C.[O:32]=[C:33]1[NH:38][C:37]2[CH:39]=[C:40](C(O)=O)[CH:41]=[CH:42][C:36]=2[S:35][CH2:34]1>>[F:27][C:25]1[C:26]2[C:17]3[CH2:16][CH:15]([CH2:14][C@H:11]4[O:10][CH2:9][C@H:8]([NH:7][C:6]([C:40]5[CH:41]=[CH:42][C:36]6[S:35][CH2:34][C:33](=[O:32])[NH:38][C:37]=6[CH:39]=5)=[O:5])[CH2:13][CH2:12]4)[O:30][C:18]=3[CH:19]=[N:20][C:21]=2[CH:22]=[CH:23][C:24]=1[O:28][CH3:29]

Participants

3

Reactant 2

HCID 7609933-oxo-3,4-dihydro-2H-1,4-benzothiazine-6-carboxylic acidHCID 86730727HCID 86730727, compound

Product 1

HCID 71475543HCID 71475543, compound

Procedure

The titled compound is prepared as an off-white lyophilized powder following Scheme 3 and in analogy to Example 13 using (3R,6S)-[6-(9-fluoro-8-methoxy-1,2-dihydro-furo[2,3-c]quinolin-2-ylmethyl)-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester and 3-oxo-3,4-dihydro-2H-benzo[1,4]thiazine-6-carboxylic acid as starting material.

Sources & evidence

ORD record
ord-bd448303948f426db77cafce8954f7a5
Source dataset
uspto-grants-2016_04
Patent number
US09321788B2

Reaction notes

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