Tetrahydrofuran → 2-Methyl-6-(tetrahydro-3-furanyl)phenol

Participants

Reaction Steps

2-(furan-3-yl)-6-methylphenol (Compound 6-9) (173 mg, 0.70 mmol) and palladium carbon (25 mg, 15%) were dissolved in methanol:tetrahydrofuran=1 mL:1 mL, followed by stirring under hydrogen balloon for 48 hours. After the completion of the reaction, the reaction mixture was filtered through Celite. The filtrate was concentrated under reduced pressure, and purified by column chromatography (hexane:ethyl acetate=3:1) to obtain 2-methyl-6-(tetrahydrofuran-3-yl)phenol (117 mg, 93%).

Provenance & Evidence