HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(Diphenylmethyl)-3-(2-thienylmethoxy)azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-(Chloromethyl)thiophene | HCID 69830 | — |
| Reactant | 1-(Diphenylmethyl)azetidin-3-ol | HCID 330448 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(Diphenylmethyl)-3-(2-thienylmethoxy)azetidine | HCID 67154602 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
To a solution of 1-diphenylmethylazetidin-3-ol (359 mg, 1.5 mmol) in DMF (1 mL) at 0° C. under nitrogen was added NaH (60% in oil, 66 mg, 1.65 mmol). The suspension was stirred for 0.5 h at 0° C. then treated with 2-(chloromethyl)thiophene (464 mg, 3.5 mmol; which may be prepared as described in Step 1) dissolved in DMF (2 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321769B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-58511c015e8f4a248fc313b19c39a685 |
| Source note | uspto-grants-2016_04 |