反应详情

4-fluoro-2-(furan-3-yl)-6-methylphenol (Compound 6-11) (471 mg, 2.45 mmol) were dissolved in methanol. Palladium carbon (64.3 mg, 5 wt %) was added thereto, followed by stirring under hydrogen balloon for 24 hours. After the completion of the reaction, the reaction mixture was filtered through Celite. The filtrate was concentrated under reduced pressure. The concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1) to obtain 4-fluoro-2-methyl-6-(tetrahydrofuran-3-yl)phenol (368 mg, 76%) as a white solid.

1. customAfter the completion of the reaction
2. filtrationthe reaction mixture was filtered through Celite
3. concentrationThe filtrate was concentrated under reduced pressure
4. customThe concentrate was purified by column chromatography (silica gel; hexane/ethyl acetate, 9/1)