反应详情

1-Chloroethyl chloroformate (65 μL, 0.60 mmol) was added to a solution of 1-benzhydryl-3-(4,4,4-trifluorobutoxy)-azetidine (200 mg, 0.57 mmol) in dichloromethane (5 mL) at 0° C. The reaction mixture was stirred for 3 hours and 30 minutes at room temperature. Ethanol (5 mL) was then added and the mixture was stirred for an additional 2 hours at 0° C. and 2 hours at 70° C. The reaction mixture was concentrated under vacuum and the residue was triturated in petroleum ether (2×20 mL) to give a colorless oil (130 mg, quantitative) which was used without further purification.

1. stirringthe mixture was stirred for an additional 2 hours at 0° C. and 2 hours at 70° C
2. concentrationThe reaction mixture was concentrated under vacuum
3. customthe residue was triturated in petroleum ether (2×20 mL)
4. customto give a colorless oil (130 mg, quantitative) which
5. customwas used without further purification