反应详情

温度

0 °C

1-Chloroethyl chloroformate (67.3 μL, 0.621 mmol) was added to a solution of 1-benzhydryl-3-(benzo[b]thiophen-3-yloxy)azetidine (220 mg, 0.592 mmol) in dichloromethane (5 mL) at 0° C. The reaction mixture was stirred for 2 hours at 0° C. and for 5 hours at room temperature. Ethanol (5 mL) was added and the reaction mixture was stirred for 1 hour at 40° C. After concentration to dryness, the crude mixture was precipitated from a mixture dichloromethane/pentane to afford a pale orange solid (140 mg, quantitative) which was used without further purification.

1. stirringthe reaction mixture was stirred for 1 hour at 40° C
2. concentrationAfter concentration to dryness
3. customthe crude mixture was precipitated from a mixture dichloromethane/pentane
4. customto afford a pale orange solid (140 mg, quantitative) which
5. customwas used without further purification