反应详情

To a solution of methyl 1H-indole-5-carboxylate (0.9 g, 5.142 mmol) in EtOH (10 mL) was added NH2NH2 (1.8 mL, 38.11 mmol). The reaction was heated at reflux for 12 h. The solvent was removed in vacuo to give a yellow solid, which was recrystallized with 60% EtOAc in n-hexane (10 mL) to afford 1H-indole-5-carbohydrazide (0.7 g, 3.98 mmol, 77.8%). MS (ESI, pos. ion) m/z: 176 (M+1).

1. temperatureThe reaction was heated
2. temperatureat reflux for 12 h
3. customThe solvent was removed in vacuo
4. customto give a yellow solid, which
5. customwas recrystallized with 60% EtOAc in n-hexane (10 mL)