Trifluoroacetic acid → HCID 68328950, compound

Participants

Reaction Conditions

Reaction Steps

A glass microwave reaction vessel was charged with N-(4-methoxybenzyl)-5-(3-(6-(3-methyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine (80.0 mg, 0.146 mmol) in TFA (1.0 mL). The reaction was heated in a microwave at 100° C. for 10 min, then solvent was removed. The residue was purified with RP-HPLC to give 5-(3-(6-(3-methyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)pyridin-2-yl)-1H-indol-5-yl)-1,3,4-thiadiazol-2-amine 2,2,2-trifluoroacetate (2.0 mg, 2.5%) as a light yellow solid. MS (ESI, pos. ion) m/z: 430 (M+1). 1H NMR (400 MHz, DMSO-d6) δ ppm 11.73 (1H, br. s.), 8.80 (1H, s), 8.14 (1H, d, J=2.0 Hz), 7.61-7.72 (2H, m), 7.52 (1H, d, J=8.6 Hz), 7.22-7.43 (3H, m), 6.90 (1H, d, J=9.2 Hz), 5.07 (2H, br. s.), 4.15-4.37 (4H, m).

Provenance & Evidence