HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Hydroxide → HCID 68328593, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 86725110 | HCID 86725110 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68328593 | HCID 68328593 | — |
Reaction Steps
6-Cyclopropyl-2-(5-(5-(isopropylamino)-1,3,4-oxadiazol-2-yl)-1-tosyl-1H-indol-3-yl)pyrimidine-4-carboxylic acid (50 mg) was treated with HATU (51.1 mg, 0.134 mmol) followed by DMF (3 mL) and Hunig's base (0.1 mL). The reaction was stirred for 30 min at RT then treated with NH4OH (0.1 mL) and stirred for 30 min. The reaction was quenched with H2O and extracted with EtOAc (50 mL) and washed with brine (3×20 mL), dried over MgSO4, filtered and concentrated. The crude residue was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321756B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-742b54c4de864557a013c7cb154b7bbb |
| Source note | uspto-grants-2016_04 |