Hydrazine → 4-(2-Phenylpropan-2-yl)thiosemicarbazide

HRID 634221Notes

Reaction equation

HRID 634221 reaction equation
[NH2:1][NH2:2].[N:3]([C:6]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([CH3:8])[CH3:7])=[C:4]=[S:5]>CCO>[C:9]1([C:6]([NH:3][C:4]([NH:1][NH2:2])=[S:5])([CH3:8])[CH3:7])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 12376018(2-Isothiocyanatopropan-2-yl)benzene

Product 1

HCID 133883954-(2-Phenylpropan-2-yl)thiosemicarbazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Anhydrous hydrazine (1.161 mL, 37.0 mmol) (Sigma-Aldrich) was added to a stirring solution of (2-isothiocyanatopropan-2-yl)benzene (6.56 g, 37.0 mmol) in EtOH (150 mL). The reaction was stirred at RT for 2 h to give N-(2-phenylpropan-2-yl)hydrazinecarbothioamide. MS (ESI, pos. ion) m/z: 210.2 (M+1). The material was used without purification.

Sources & evidence

ORD record
ord-dafd415e8bd1486ba2c2f37684491cb3
Source dataset
uspto-grants-2016_04
Patent number
US09321756B2

Reaction notes

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