Hydrazine → 1-Amino-3-(2,2,2-trifluoroethyl)thiourea

HRID 634224Notes

Reaction equation

HRID 634224 reaction equation
[NH2:1][NH2:2].[F:3][C:4]([F:10])([F:9])[CH2:5][N:6]=[C:7]=[S:8]>CCO>[F:3][C:4]([F:10])([F:9])[CH2:5][NH:6][C:7]([NH:1][NH2:2])=[S:8]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 138837771,1,1-Trifluoro-2-isothiocyanatoethane

Product 1

HCID 337883111-Amino-3-(2,2,2-trifluoroethyl)thiourea

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Anhydrous hydrazine (0.634 mL, 20.20 mmol) (Sigma-Aldrich) was added to a stirring solution of 1,1,1-trifluoro-2-isothiocyanatoethane (2.85 g, 20.20 mmol) in EtOH (80 mL). The reaction was stirred at RT for 2 h. The solvent was removed in vacuo to give N-(2,2,2-trifluoroethyl)hydrazinecarbothioamide, and the material was used without purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-a459b311cb304e80a6c5d8a345f664ff
Source dataset
uspto-grants-2016_04
Patent number
US09321756B2

Reaction notes

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