2-bromo-N-cyclopropyl-4-Thiazolecarboxamide → HCID 136348497, compound

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Reaction Steps

The title compound (34 mg, 30% yield) as a yellow crystalline solid was prepared according to Example 275, using N-isopropyl-5-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-indol-5-yl)-1,3,4-oxadiazol-2-amine (145 mg, 0.278 mmol), 2-bromo-N-cyclopropylthiazole-4-carboxamide (75 mg, 0.305 mmol), and Pd(PPh3)4 (Strem Chemicals, 16 mg) as the starting materials and reagent. 1H NMR (400 MHz, DMSO-d6) δ ppm 12.15 (1H, br.), 8.57 (1H, s), 8.29 (2H, m), 8.15 (1H, s), 7.74 (1H, d, J=7.4 Hz), 7.65 (2H, d, J=8.6 Hz), 3.77 (1H, m), 2.90 (1H, m), 1.25 (6H, d, J=6.1 Hz), 0.75 (2H, m.), 0.69 (2H, m). MS (ESI, pos. ion) m/z 409.1 (M+H)+.

Provenance & Evidence