Ammonia → HCID 68328641, compound

Participants

Reaction Steps

To a solution of 3-fluoro-4-(5-(5-(isopropylamino)-1,3,4-oxadiazol-2-yl)-1-tosyl-1H-indol-3-yl)benzoic acid (500 mg, 0.936 mmol) in DMF (10 mL) was added EDC HCl (269 mg, 1.40 mmol) followed by HOBt and NH3 (284 mg, 1.87 mmol). The reaction was stirred at RT for 1 h, then quenched with ice cold water (20 mL) to get a precipitate. The precipitate was filtered, washed with water (2×100 mL) and dried to give the crude product (250 mg). MS (ESI, pos. ion) m/z: 534.1 (M+1).

Provenance & Evidence