Cesium carbonate → 4-(2-Fluorophenyl)-3-(hydroxymethyl)-1H-isochromen-1-one

Participants

Reaction Steps

The title compound was made in a similar way as that of the intermediate B2 using 4-bromo-3-(hydroxymethyl)-1H-isochromen-1-one (Intermediate A1, 0.6 g, 2.352 mmol), 2-fluorophenylboronic acid (0.494 g, 3.53 mmol), Pd(PPh3)4 (0.136 g, 0.118 mmol) and Cs2CO3 (0.77 g, 2.35 mmol) to afford the title compound (0.21 g, 33%).

Provenance & Evidence