HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 3-(Hydroxymethyl)-4-m-tolyl-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Tolylboronic acid | HCID 2733950 | — |
| Reactant | 4-bromo-3-(hydroxymethyl)-1H-isochromen-1-one | HCID 16050022 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 3-(Hydroxymethyl)-4-m-tolyl-1H-isochromen-1-one | HCID 118131116 | 40.2% |
Reaction Steps
The title compound was made in a similar way as that of the intermediate B2 using 4-bromo-3-(hydroxymethyl)-1H-isochromen-1-one (Intermediate A1, 0.5 g, 1.96 mmol), m-tolylboronic acid (0.400 g, 2.94 mmol), Pd(PPh3)4 (0.113 g, 0.098 mmol) and Cs2CO3 (0.64 g, 1.96 mmol) to afford the title compound (0.21 g, 40%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a0711e45b1de46959e6e5f211da5945a |
| Source note | uspto-grants-2016_04 |