HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 3-(1-Hydroxyethyl)-4-m-tolyl-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Tolylboronic acid | HCID 2733950 | — |
| Reactant | 4-Bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one | HCID 118131255 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 3-(1-Hydroxyethyl)-4-m-tolyl-1H-isochromen-1-one | HCID 118131250 | 55.5% |
Reaction Steps
The title compound was made in a similar way as that of the intermediate B1 using 4-bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one (Intermediate A2, 0.52 g, 1.93 mmol), m-tolylboronic acid (0.45 g, 3.28 mmol), Pd(PPh3)4 (0.11 g, 0.096 mmol) and Cs2CO3 (0.81 g, 2.5 mmol) to afford the title compound (0.3 g, 55%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-197b5b8874264638a02d0bda94b76d38 |
| Source note | uspto-grants-2016_04 |