HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 4-(3-Fluorophenyl)-3-(1-hydroxyethyl)-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Fluorophenylboronic acid | HCID 2733986 | — |
| Reactant | 4-Bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one | HCID 118131255 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 4-(3-Fluorophenyl)-3-(1-hydroxyethyl)-1H-isochromen-1-one | HCID 118131078 | 46.2% |
Reaction Steps
The title compound was made in a similar way as that of the intermediate B1 using 4-bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one (Intermediate A2, 0.8 g, 2.97 mmol), 3-fluorophenylboronic acid (0.62 g, 4.46 mmol), Pd(PPh3)4 (0.17 g, 0.149 mmol) and Cs2CO3 (0.97 g, 2.9 mmol) to afford the title compound (0.39 g, 46%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-7be990d787c44b33911cd4fd9d899f55 |
| Source note | uspto-grants-2016_04 |