HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → 3-(1-Hydroxyethyl)-4-(6-methylpyridin-3-yl)-1H-isochromen-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 2-Methylpyridine-5-boronic acid | HCID 2763081 | — |
| Reactant | 4-Bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one | HCID 118131255 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | 3-(1-Hydroxyethyl)-4-(6-methylpyridin-3-yl)-1H-isochromen-1-one | HCID 118131108 | 29% |
Reaction Steps
The title compound was made in a similar way as that of the intermediate B1 using 4-bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one (Intermediate A2, 0.55 g, 2.04 mmol), 6-methylpyridin-3-ylboronic acid (0.550 g, 2.0 mmol), Pd(PPh3)4 (0.118 g, 0.102 mmol) and Cs2CO3 (1.06 g, 3.27 mmol) to afford the title compound (0.163 g, 28%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09321776B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-a687e421b1de4a43a025f66b39006fe0 |
| Source note | uspto-grants-2016_04 |