Cesium carbonate → tert-Butyl 4-(3-(1-hydroxyethyl)-1-oxo-1H-isochromen-4-yl)-5,6-dihydro-pyridine-1(2H)-carboxylate

Participants

Reaction Steps

The title compound was made in a similar way as that of the intermediate B1 using 4-bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one (intermediate A2, 0.55 g, 2.04 mmol), tert-butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (0.79 g, 2.55 mmol), Pd(PPh3)4 (118 mg, 0.102 mmol) and Cs2CO3 (1.0 g, 3.27 mmol) to afford the title compound (0.135 g, 18%) as a yellowish oil.

Provenance & Evidence