Cesium carbonate → HCID 118131074, compound

Participants

Reaction Steps

The title compound was made in a similar way as that of the intermediate B1 using 4-bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one (Intermediate A2, 0.5 g, 1.86 mmol), 2-methylpyridin-4-ylboronic acid (0.38 g, 2.79 mmol), Pd(PPh3)4 (0.107 g, 0.093 mmol) and Cs2CO3 (0.78 g, 2.41 mmol). The crude was purified via reverse phase chromatography with a Biotage C18 SNAP 30 g column (Phase A, water 95%, ACN 4.9%, formic acid 0.1%; Phase B ACN 99.9%, formic acid 0.1%) to afford the title compound (0.25 g, 48%).

Provenance & Evidence