Cesium carbonate → HCID 118131268, compound

Participants

Reaction Steps

The title compound was made in a similar way as that of the intermediate B1, using 4-bromo-3-(1-hydroxyethyl)-1H-isochromen-1-one (Intermediate A2, 0.6 g, 2.23 mmol), 6-methoxypyridin-3-ylboronic acid (0.443 g, 2.90 mmol), Pd(PPh3)4 (0.206 g, 0.178 mmol) and Cs2CO3 (1.02 g, 3.1 mmol). The crude was purified via reverse phase chromatography on the Biotage 30 g C18 SNAP column (Phase A, water 95%, acetonitrile 4.9%, formic acid 0.1%; Phase B acetonitrile 99.9%, formic acid 0.1%) to afford the title compound (0.25 g, 38%).

Provenance & Evidence