反应详情

1 M PBr3 in DCM (2.3 ml, 2.332 mmol) was added to a solution of 4-(3-fluorophenyl)-3-(1-hydroxyethyl)-1H-isochromen-1-one (intermediate B7, 390 mg, 1.372 mmol) in DCM (7.8 ml) and the mixture stirred at RT for 2 hrs. The reaction mixture was then evaporated under reduced pressure and purified on a silica Biotage SNAP 100 g, eluting with a gradient of hexane and EtOAc to give the title (227 mg, 47.7%).

1. customThe reaction mixture was then evaporated under reduced pressure
2. custompurified on a silica Biotage SNAP 100 g
3. washeluting with a gradient of hexane and EtOAc
4. customto give the title (227 mg, 47.7%)