Phosphorus tribromide → HCID 118131091, compound

Participants

Reaction Steps

1 M PBr3 in DCM (0.105 mL, 1.105 mmol) was added to 4-benzyl-3-(1-hydroxyethyl)-1H-isochromen-1-one (Intermediate B14, 625 mg, 2.230 mmol) in DCM (2 ml) at RT. Reaction mixture was straightforward purified on Biotage SNAP 25 g silica cartridge with a gradient of hexane and EtOAc to give the title compound (22 mg, 2.9%).

Provenance & Evidence