Phosphorus tribromide → HCID 118131409, compound

Participants

Reaction Steps

1 M PBr3 in DCM (846 μL, 0.846 mmol) was added to of 3-(1-hydroxyethyl)-4-(2-methylpyridin-4-yl)-1H-isochromen-1-one (intermediate B13, 140 mg, 0.498 mmol) in DCM at RT. Reaction mixture was concentrated under reduced pressure and straightforward purified via reverse phase chromatography with a Biotage C18 SNAP 60 g column (Phase A, water 95%, ACN 4.5%, formic acid 0.5%); Phase B ACN 99.5%, formic acid 0.5%) to give the title compound (80 mg, 45%).

Provenance & Evidence