反应详情

1 M PBr3 in DCM (1.82 mL, 1.82 mmol) was added to 3-(1-hydroxyethyl)-4-(4-(2-morpholinoethoxy)phenyl)-1H-isochromen-1-one (Intermediate B15, 180 mg, 0.455 mmol) in DCM (2 ml) at RT. The reaction mixture was then was diluted with Et2O and filtered. The residue was further washed with Et2O and finally dried to give the title compound (150 mg, 61%) as a pink-red solid.

1. filtrationfiltered
2. washThe residue was further washed with Et2O
3. customfinally dried